Saturday, September 29
Kick-off: 17.30 BST
TV: Live ESPN, Highlights BBC1 Match of the Day.
United (Possible, 4-4-1-1): Lindegaard; Rafael, Ferdinand, Evans, Evra;
Nani, Carrick, Giggs, Valencia; Kagawa; Van Persie.
Out: Vidic, Jones, Young (all knee), Smalling (foot).
Test: Valencia (ankle).
Tottenham (Possible, 4-1-4-1): Friedel; Walker, Gallas, Vertonghen,
Naughton; Sandro; Lennon, Dembélé, Sigurdsson, Bale; Defoe.
Out: Adebayor (hamstring), Gomes (ankle), Parker (Achilles), Livermore (groin), Assou-Ekotto, Kaboul (both knee).
Test: Naughton (foot).
Referee: Chris Foy. Matches 4, R0 Y5.
Antonio Valencia is Manchester United's major injury concern ahead of the Premier League encounter with Tottenham at Old Trafford.
The Ecuador wide-man suffered a nasty knock on his ankle at Liverpool last week and Sir Alex Ferguson rates Valencia as "doubtful".
Darren Fletcher and Scott Wootton are both in the United squad but are unlikely to play from the outset and Robin van Persie and Wayne Rooney could start together for the first time.
Meanwhile, Brad Friedel will return in goal for Tottenham's trip to Manchester United in the Premier League.
Hugo Lloris will be on the bench and defender Kyle Naughton could return after missing last week's win over QPR with a foot injury he sustained against Lazio.
Emmanuel Adebayor, Scott Parker, Jake Livermore, Benoît Assou-Ekotto and Younes Kaboul are out.
With Wayne Rooney back to fitness following his month-long lay-off with a badly gashed thigh, Tottenham could become the first team to face the prospect of a Rooney-Robin van Persie strike partnership at Old Trafford.
Injury and lack of fitness have prevented the pair from starting together in a United shirt so far this season, but Sir Alex Ferguson signed Van Persie with the intention of him forming a prolific double act with Rooney and, sooner or later, somebody is going to have to face.
Tottenham, without a league victory at Old Trafford since December 1989, would prefer to see their partnership delayed.
Betting: Home 11-20, Away 9-2, Draw 3-1.
Stat of the game: Spurs have failed to beat Manchester United in their last 22 Premier League meetings.
Mark Ogden’s prediction: Manchester United 2 Tottenham 1.